Cannabidiol (CBD) in Hashimoto’s thyroiditis: studies and important pointers

CBD is very popular right now and is used for various diseases and ailments. Cannabidiol has many different effects on our body and it is also said to be helpful in autoimmune processes. People who suffer from Hashimoto’s disease are also interested in the natural hemp active ingredient CBD.

CBD is a non-psychoactive cannabinoid that is currently available over-the-counter in the form of CBD oils or hemp teas containing CBD.

To what extent could CBD influence the disease dynamics in Hashimoto’s disease or alleviate typical symptoms of those affected?

The following article shows the previous research on this topic and provides information on what to consider when using CBD, for example which interactions, contraindications and side effects of CBD have to be considered.

CBD in Hashimoto’s disease: Its effect on autoimmune diseases

CBD is currently the subject of intensive research because its broad effect seems to allow therapeutic use in many different diseases and ailments. CBD affects messenger substances in the central nervous system, the metabolism of the skin, the development of pain, the growth of cancer cells, inflammatory processes, the immune system and our mental life.

It can have antiepileptic, antipsychotic, anti-inflammatory, analgesic, antidepressant and antitumor effects. It also provides a new therapeutic approach for autoimmune diseases.

Like many cells in the body, defense cells also form so-called cannabinoid receptors. Endogenous endocannabinoids exert their effect on these receptors. These are messenger substances that are similar in structure and effect to the main active substances in cannabis (hemp), the so-called cannabinoids.

Due to the structural relationship, cannabinoids such as CBD also interact with cannabinoid receptors. Among other things, they can have a regulating effect on the activity of immune cells and regulate the secretion of pro-inflammatory substances such as cytokines. The effect of CBD on regulatory T cells, which play a major role in autoimmune diseases, has been particularly well researched. (1)

Read More  What exactly is Hashimoto's thyroiditis?

In autoimmune processes we often find an imbalance between Th1 and Th2 cells. Th1 dominance prevails, for example, in autoimmune diseases such as multiple sclerosis (MS), chronic inflammatory bowel diseases (ulcerative colitis, Crohn’s disease), psoriasis or Hashimoto’s disease.

Th2 dominance can be demonstrated in lupus erythematosus, scleroderma and in about one fifth of Hashimoto’s patients, among others. MS studies suggest that cannabinoids such as CBD can have a beneficial effect on Th1 dominance. (2) The regulatory properties of CBD could also be helpful in Th2 dominance.

The high antioxidant potential of CBD can also play a role in autoimmune processes. Oxidative stress is known to be involved in the persistence of autoimmune diseases. (3) This also applies to Hashimoto’s disease.

CBD for typical symptoms of Hashimoto’s disease

Cannabidiol may be helpful for Hashimoto’s thyroiditis

People who suffer from Hashimoto’s disease usually complain of many different symptoms . For some, the use of CBD could be helpful. These include tiredness, sleep disorders, depression, nervousness, fears or dry skin.

According to studies, CBD can help with both fatigue and sleep disorders. Research results and practical experience suggest that low doses of CBD (e.g. less than or equal to 20 milligrams per day) have a stimulating and invigorating effect on tired or exhausted people.

Larger doses, on the other hand, promote sleep and can make you tired. (4) The effects of CBD on fatigue and tiredness appear to be closely linked to the metabolism of the endocannabinoid anandamide.

Anandamide is formed by our body itself and has an invigorating, pain-relieving and mood-enhancing effect via the cannabinoid receptors. The American cannabis researcher Ethan Russo suspects that fatigue can be a symptom of clinical endocannabinoid deficiency, in which, among other things, anandamide is not sufficiently present.

Read More  Vitamin D and Hashimoto's thyroiditis - the connections quickly explained

CBD is recommended for anandamide deficiency. CBD inhibits the enzyme responsible for breaking down anandamide and can therefore ensure higher levels of anandamide in the body. (5)

CBD also has both antidepressant and anxiolytic effects. Depression and anxiety are not uncommon in people with Hashimoto’s thyroiditis . Again, if CBD is helpful, it could be due to its effects on anandamide metabolism.

It could also help with the various gastrointestinal issues that people with Hashimoto’s disease often complain about. The endocannabinoid anandamide has a pain-relieving effect in the digestive tract and has a calming effect on digestion. CBD can actively support digestion accordingly.

In case of dry skin, the effect of CBD on the production of skin fats could be helpful. In order to additionally support this, the intake of oils containing gamma-linolenic acid (hemp oil, borage oil or evening primrose oil) is recommended.

Use CBD correctly

Over-the-counter CBD is taken in the form of CBD oils or hemp teas containing CBD. With the former, it is an advantage if they not only contain CBD, but also other active ingredients from the hemp plant. The consumption recommendations of the manufacturer should be taken into account when using the product. Taking CBD oils with a fatty meal increases the absorption of CBD in the digestive tract.

Hemp teas should always be drunk with something fatty like cream, milk or coconut oil as this facilitates the absorption of CBD. The use of hemp blossoms is particularly recommended for the production of hemp tea.

Pay attention to contraindications, interactions and side effects of CBD

Before taking CBD, possible interactions and side effects, as well as contraindications, must be observed. Contraindications are glaucoma (glaucoma) and severe liver damage. During pregnancy , if you are allergic to hemp or its ingredients and if your liver metabolism is impaired, CBD should only be used with medical approval. In pregnant women, CBD can impair the protective function of the uterus.

CBD influences various enzymes CYP2C9, CYP2C19, CYP3A4 and CYP2D6, which are also responsible for the breakdown of various drugs. This can lead to medication such as painkillers, anticoagulants, acid blockers or neuroleptics having a stronger effect than intended.

Read More  Hashimoto's thyroiditis and the struggle with obesity

Other drugs that are metabolized via the enzymes mentioned above can also be affected. Anyone taking medication should therefore seek medical advice before using CBD.

Common low dosages of CBD (e.g. 20 milligrams per day) are usually not associated with any side effects. Higher doses can make you tired, irritable, and suppress your appetite. The latter is particularly problematic in the case of underweight or eating disorders.

Does CBD change thyroid hormone metabolism?

Unfortunately, little is currently known about whether CBD can change the metabolism of thyroid hormones. The few research results suggest that CBD neither promotes nor inhibits the formation of thyroid hormones. According to an animal study, another active ingredient in hemp, the psychoactive THC, can inhibit the formation of the hormone triiodothyronine (T3). (6)

Promote the effects of CBD with your lifestyle

CBD acts on our endocannabinoid system, a complex of many different messenger substances and receptors. The healthier the endocannabinoid system, the better CBD can work. Our endocannabinoid system is directly affected by our lifestyle.

How we eat, how much we sleep or how we exercise all affect our endocannabinoids like anandamide. This should also be taken into account in people with Hashimoto’s.

According to McPartland’s research, the following recommendations strengthen the endocannabinoid system:

  • relaxation techniques such as meditation or yoga,
  • Omega-3 oils, high-quality vegetable oils,
  • calorie-conscious diet ,
  • regular physical activity,
  • probiotic foods (e.g. yoghurt, kefir, sauerkraut, kimchi, kombucha, apple cider vinegar, lactic acid fermented vegetables)
  • dietary fiber and
  • the reduction of potentially harmful chemicals such as pesticides and plasticizers in the diet. (7)

Important to note

The use of CBD in the context of Hashimoto’s disease should always be clarified with the doctor treating you. The use of CBD and the information in this article cannot replace medical diagnosis or therapy for thyroid diseases.

Related Posts

Leave a Reply

Your email address will not be published.