HPU / KPU: A metabolic disorder with fatal consequences for the organism

The HPU/KPU (haemopyrrolic actamuria) is one of the most frequently occurring metabolic disorders, but also one of the most ignored diseases in conventional medicine here, which to this day is very rarely versed in relation to HPU/KPU.

Since the so-called pyrrolics suffer from severe multi-organ complaints and also psychological difficulties, they are usually permanent guests of various doctors and psychologists , where, however, usually only individual symptoms are treated and the metabolic disease continues to progress.

The torments of the patients are absolutely unnecessary, since a clever diagnosis is very easy to grasp and the treatment is also very simple. Provided one has found a doctor who is a little versed on this subject.

What exactly is haemopyrrolic actamuria?

HPU/KPU is a biochemical disorder in the synthesis of the red blood pigment, which is usually genetic or acquired. HPU/KPU is a common cause for a wide variety of clinical pictures , in which the doctor cannot find the origin.

In the case of hemopyrrolic actamuria, there are problems with the synthesis of the red blood pigment hemoglobin. Various problems result from this.

The formation of heme is severely disturbed , which plays a decisive role in energy metabolism and is also needed for detoxification. In addition, heme is responsible for the oxygen supply to the muscles.

In addition, a type of harmful heme is produced, which cannot easily leave the body, since the detoxification of this substance is impeded due to the HPU/KPU. In this case, the body uses a trick and binds  vitamin B6 ,  zinc  and manganese to the wrong heme, which can then be excreted in the urine.

In this way, the body gets rid of the harmful substances, but at the same time loses essential vitamins that are needed for more than one hundred metabolic processes in the body.

However, the loss of vitamins in pyrrolic sufferers can no longer be compensated for with food, so that the problem is usually not recognized and the situation can only become more difficult over time. In this way, more and more complaints arise and at most only the symptoms are treated, but the patient becomes more and more ill.

HPU/KPU can have a genetic cause and is often inherited. If the parents suffer from a thyroid disease or psychological problems, the HPU/KPU should always be considered as an offspring with health problems.

However, you can also acquire this disease in the course of life. Two reasons for this are currently being discussed. For one, reports Dr. Bodo Kulinski that cervical vertebral diseases can trigger the HPU/KPU. On the other hand, there are also many indications that heavy metal pollution from mercury in particular can be responsible for this disorder .

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What does HPU/KPU mean for health?

One of the most important functions in the human body is constant detoxification. Every day we take in considerable amounts of pollutants through the air, food, medicines or stimulants. These pollutants must also leave the body immediately, otherwise illnesses and health restrictions would arise.

A healthy body can master this task, but unfortunately this is very different for a pyrrole sufferer. The excreted vitamins and minerals vitamin B6,  zinc  and manganese are essential for the body’s own detoxification.

A lack of these lost vital substances becomes clearly noticeable from a certain level and becomes a serious and momentous problem for the body. Many metabolic processes become weaker and weaker over time and the body’s own detoxification also collapses.

More and more pollutants accumulate in the tissues and organs , which has an enormous impact on the body in the long run. In this way, more and more symptoms and health problems arise.

Especially when heavy metals come into play. The body can only detoxify these very poorly anyway, but in the case of pyrrolic sufferers they are stored in the tissue and are up to mischief there.

Usually with fatal consequences, since many essential enzymes are now also blocked in addition to the problems mentioned, which means that even more metabolic and detoxification processes in the body can only take place partially or not at all .

Typical HPU-KPU symptoms and complaints

  • pale complexion
  • various anemias (iron or B vitamins)
  • white patches under the fingernails
  • tiredness / weakness
  • poor memory – especially short-term memory
  • hypoglycaemia
  • Inflammation in the gastrointestinal tract
  • constipation
  • food intolerances
  • Histaminintoleranz
  • allergies
  • morning sickness
  • lack of stress resistance
  • adrenal fatigue
  • joint pain
  • Muscle aches
  • mental health problems, depression, schizophrenia, anxiety, restlessness
  • low blood pressure and heart rate
  • Hypersensitivity to sunlight
  • Cardiac and vascular diseases (elevated homocysteine)
  • At a young age: increased mobility of the joints (hypermobility)
  • In old age, the opposite is the case: the joints become immobile and stiff
  • Sugar problems: fructose intolerance and type 2 diabetes
  • insomnia
  • loss of appetite

In addition, the HPU/KPU contributes to other diseases, triggers them or aggravates them:

  • adrenal fatigue
  • Hashimoto-Thyreoiditis
  • other thyroid disorders (underactive or overactive)
  • PBC (autoimmune liver disease)
  • Diabetes Typ 2
  • ADS / ADHS
  • autism
  • Intensification of addiction to various substances
  • migraine
  • Bipolar psychoses, panic disorders, depression
  • Mitochondriopathien

How is the HPU/KPU diagnosed?

For a long time, only the classic cryptopyroll test (KPU) was available, which, however, is very imprecise and does not make it possible to detect specific metabolic disorders. Instead, only pyrole compounds are measured in the urine.

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Since 2000, the original HPU® test has been available , which is now much more accurate and able to measure specific HPL complexes that are unique to the HPU in the form formed. Because of this, it should also be clear that HPU is not the same as KPU, although both diseases are often presented as one disease with two names.

There are two variants of the original HPU® test. Firstly, the more cost-effective variant, in which only the morning urine is examined. This is chosen if the symptoms have only existed for a short time and this test variant is also sufficient for children.

If the symptoms have existed for some time and the person concerned is chronically ill, you should choose the 24-hour urine test, as this is more accurate and also covers the so-called evening excretions. Many patients with a long history of HPU/KPU excrete the HPL complexes often 1-2 hours after meals or overnight. Therefore, the simple morning urine test could be falsely negative in such a case.

How is HPU/KPU treated?

Actually quite simple. And only with micronutrients, minerals and trace elements . The micronutrients that are excreted and missing from the body must be administered orally.

according to dr Kamsteeg, many HPUers have problems activating vitamin B6, which is why it is recommended to substitute the activated vitamin B6 in the form of P-5-P directly. The amount in adults is about 50-100mg/day. However, the need can vary from patient to patient. However, a daily dose of 2000mg should not be exceeded.

Furthermore,  zinc must be  replaced. In what form is a matter of faith and everyone prefers a different form. dr Kamsteeg recommends zinc gluconate, others prefer zinc citrate. Personally, I’m hooked on zinc orotate . So everyone should decide for themselves. The recommended daily dose for zinc is 30-60mg. Although there are also patients who need 125mg and more.

And if zinc is supplied, manganese should not be missing either. A daily dose of 10-20mg is recommended. There are now various providers on the market who offer so-called combination preparations with the micronutrients mentioned above.

dr Kamsteeg offers different variants of its Depyrrole, Heidelberger Chlorella the B-LIFE Protect and Monapur the Kryptosan. However, since it is often recommended to take the zinc twice a day, as well as the manganese, such a split is difficult to manage with combination supplements, which is why I personally use all three micronutrients separately.

In addition to these three important micronutrients, pyrrolic sufferers should always keep an eye on and compensate for the lack of other micronutrients, as there are often deficits here. Especially since the intestine is often damaged due to intolerance and therefore cannot absorb enough micronutrients.

Tips on dosing

It is not decisive how high the result of the HPU test is and you cannot determine the dosage of the micronutrients from the test result.

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There are patients who have very high HPL values, have few complaints and therefore also need low doses of micronutrients. On the other hand, there are patients who have low HPL values, have massive complaints and also have to take quite high doses of micronutrients.

But in the end, each patient has to find the appropriate dosage for themselves. It is optimal if manganese and zinc are split into two doses . One serving in the morning for the P5P and the second dose in the evening.

P5P (active vitamin B6)

At the beginning you should always sneak P5P very carefully, since it can lead to various side effects. Severe nausea can occur, fatigue can increase significantly, but psychological symptoms can also flare up.

Because the metabolism is ramping up again and the detoxification gets going again, it is possible that symptoms of poisoning will appear and, if necessary, heavy metals will be mobilized.

So you should start with a low dose (12.5mg) and then carefully increase it every few days or weeks. A good marker to use as a guide when it comes to dosing is the dream memory.

If you can remember your dreams well, you are very close to the ideal dose. Most of the time, the P5P dose levels off between 50-100mg. However, there are also patients who need significantly more.


When it comes to zinc dosage, opinions differ and a wide variety of information can be found on the Internet.

It is often recommended to take between 30-50mg, Dr. Kamsteeg writes in his book “HPU…und then?” that 30mg in the morning and in the evening would be a good start. So you have to see for yourself where the journey is going, but you have to get in low at first. 12.5mg is a good start and can be increased further after 2-3 weeks.

Since zinc displaces mercury and copper in the body, symptoms of poisoning can also occur here if the dose is too high. However, the zinc compound used is also important. Zinc is available as orotate, citrate, aspartate, gluconate, etc. Most of the time, gluconate is recommended, although I personally prefer orotate. Here, too, you have to try and see what suits you best.


Since manganese is also lost in HPU, this must also be substituted. The more zinc is ingested, the more manganese must be ingested.

In the beginning it should not be more than 5mg. In the later course you can also dose up to 20mg high. Since manganese displaces copper, symptoms of poisoning can also occur here if the dose is too high. Manganese should always be taken slightly later than zinc, as it inhibits zinc absorption.

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