What is zoledronic acid? Why is it used? How does it affect the body? Who should use this medicine and who should not? What are the precautions to be taken before use? Are there any side effects? What are the medicines containing zoledronic acid? You can find the answers to all these questions and much more below.

What is zoledronic acid?

Zoledronic acid is used to prevent or treat osteoporosis in men and women taking glucocorticoids (a type of corticosteroid medicine that can cause osteoporosis ) , especially in menopausal women, to prevent or treat osteoporosis (a condition in which bones become thin and weak and break easily). used to do.

Zoledronic acid is also used to treat Paget’s disease (a condition in which bones are soft and weak and can become deformed, painful, or break easily), to treat high levels of calcium in the blood that can be caused by certain types of cancer. Zoledronic acid is also used with cancer chemotherapy to treat bone damage caused by multiple myeloma (cancer that begins in plasma cells) or cancer that begins in another area .

Zoledronic acid is not cancer chemotherapy and will not slow or stop the spread of cancer. But it can be used to treat bone disease in patients with cancer. Zoledronic acid is in a class of medications called bisphosphonates . It works by slowing bone breakdown, increasing bone density, and reducing the amount of calcium released from bones into the blood.

How to use Zoledronic acid?

Zoledronic acid is used as a solution (liquid) to be injected into a vein over at least 15 minutes. It is usually injected by a doctor or nurse in a doctor’s office, hospital, or clinic.

When zoledronic acid injection is used to treat high blood calcium levels caused by cancer, it is usually given as a single dose. A second dose may be given at least 7 days after the first dose if blood calcium does not fall or remain at normal levels. When used to treat bone damage caused by multiple myeloma or cancer that has spread to the bones, it is usually given every 3 to 4 weeks.

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Zoledronic acid injection is usually given once a year when used to treat osteoporosis in men and menopausal women, or to treat or prevent osteoporosis in people taking glucocorticoids. When used to prevent osteoporosis in menopausal women, it is usually given every 2 years. When used to treat Paget’s disease, it is usually given as a single dose, but additional doses may be given after some time.


It is important that you drink at least 2 glasses of water or another liquid within a few hours before taking zoledronic acid.

Your doctor may prescribe or recommend a multivitamin containing calcium supplements and vitamin D to take during your treatment. You should take these supplements every day as prescribed by your doctor. You should tell your doctor if there is any reason why you cannot take these supplements during your treatment.

You may experience a reaction in the first few days after receiving a dose of zoledronic acid injection. Symptoms of this reaction may include flu-like symptoms, fever, headache , chills, and bone, joint, or muscle pain. These symptoms may begin within the first 3 days after receiving the injection and may last 3 to 14 days. Your doctor may tell you to take an over-the-counter pain reliever/fever reducer after receiving zoledronic acid injection to prevent or treat these symptoms.

If you are receiving zoledronic acid injections to prevent or treat osteoporosis, you should continue to take the medicine as scheduled, even if you feel well. You should talk to your doctor from time to time about whether you still need to be treated with this medicine.

Also, if you forget to take your medicine, you should take it as soon as possible.


This medicine may also be prescribed for other uses; Ask your doctor or pharmacist for more information.

What are the precautions to be taken before taking zoledronic acid?

Precautions to be taken before taking zoledronic acid are as follows:

  1. You should tell your doctor if you are allergic to zoledronic acid and its ingredients, to any other drugs, or to any of them.
  2. Tell your doctor about any prescription and over-the-counter medications, vitamins, supplements, and herbal products you are taking or planning to take. Many drugs can interact with zoledronic acid, so tell your doctor about all medications you are taking. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  3. Tell your doctor if you have kidney disease or if you have dry mouth, dark urine, decreased sweating, dry skin, and other signs of dehydration. Your doctor will wait until you are dehydrated before giving you an injection of zoledronic acid, or if you have certain types of kidney disease, this treatment may not be suitable for you. Also, let your doctor know if you have ever had a low calcium level in your blood. Your doctor will likely check the calcium level in your blood before starting treatment, and if the level is too low, this medicine may not be suitable for you.
  4. Tell your doctor if you have been treated with zoledronic acid and other bisphosphonates in the past. Also, let your doctor know if you have a past or ongoing problem.
  5. Tell your doctor if you are pregnant, planning to become pregnant or are breastfeeding. You should use a reliable method of birth control to prevent pregnancy while taking zoledronic acid. Even if you become pregnant, inform your doctor. Zoledronic acid may harm the fetus. Talk to your doctor if you plan to become pregnant at any time in the future, because this medicine can stay in your body for years after you stop taking it.
  6. you should know that zoledronic acid injection may cause severe bone, muscle, or joint pain. You may start to feel this pain within days or months after taking this medicine for the first time. You should tell your doctor if you experience severe pain at any time during your treatment. Your doctor may stop giving you injections of zoledronic acid, and your pain may go away after you stop treatment with this medicine.
  7. you should know that zoledronic acid may cause osteonecrosis of the jaw (a serious condition of the jawbone). Before you start using the medicine, a dentist should examine your teeth and perform any necessary treatments, including cleaning. Check with your doctor before having any dental treatment while using this medicine.


Unless your doctor tells you otherwise, you should continue with your normal diet.

What are the side effects of Zoledranic acid?

Zoledronic acid may cause side effects. If any of the following symptoms are severe or do not go away, inform your doctor:

  • If you have itching, redness, pain or swelling where you received the injection
  • If you have redness, itching, watering or swelling in the eyes
  • If you are constipated
  • if you have nausea
  • if you are vomiting
  • if you have diarrhea
  • if you have abdominal pain
  • If you have loss of appetite
  • If there is weight loss
  • There is a painful burning sensation in the chest
  • If you have mouth sores
  • If you feel excessively anxious
  • if you are depressed
  • If you have trouble falling asleep or staying asleep
  • If you have fever, chills, cough, and other signs of infection
  • If you have white spots in the mouth
  • If you have swelling, redness, irritation, burning or itching in the vagina
  • If you have a white vaginal discharge
  • If you have numbness or tingling around the mouth or in the fingers and toes
  • If your hair is falling out
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Some side effects can be serious. If you experience any of the following symptoms, you should seek immediate medical attention:

  • Skin rash and itching
  • swelling of the eyes, face, lips, tongue, throat, hands, arms, feet, ankles, or lower legs
  • hoarseness
  • Difficulty breathing or swallowing
  • upper chest pain
  • irregular heartbeat
  • Muscle spasms, twitches, or cramps
  • unusual bruising or bleeding
  • painful or swollen gums
  • loosening of teeth
  • Numbness or heaviness in the jaw
  • Pain that does not heal in the mouth or jaw


Zoledronic acid may cause other side effects as well. Tell your doctor if you have any unusual problems while using this medicine.

Being treated with a bisphosphonate medicine such as zoledronic acid injection for osteoporosis may increase your risk of breaking your thighbone(s). For several weeks or months before the bone(s) break, you may experience a dull, aching pain in your hips, groin, or thighs, and you may find that one or both of your thigh bones are broken, even if you have not experienced trauma to the area (such as from a fall). It is unusual for a thigh bone to break in healthy people, but this bone can break even if people with osteoporosis do not receive an injection of zoledronic acid.

What are the medicines containing zoledranic acid?

Medicines containing zoledronic acid in our country include the following:

  • Aclasta 5mg/100ml
  • Bonedro 4mg/5ml
  • Lusima 5mg/100ml
  • Lusima 5mg/100ml
  • Ossi 4mg / 5ml
  • Ostezoles 4mg/5ml
  • Ronix 4mg/5ml
  • Vertebzol 5mg/100ml
  • Xendro 5mg/100ml
  • Zodinasil 5mg/100ml
  • Zoledrin 4mg/5ml
  • Zolegen 4mg/5ml
  • Zolenat 4mg/5ml
  • Zoloporoz 5mg/100ml
  • Zoltasta 4mg/5ml
  • Zoltonar 5mg/100ml
  • Zomebon 4mg/5ml
  • Zometa 4mg
  • Zoronic 4mg/5ml
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Remember, your doctor will decide which medicine to take and how.

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